Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer

Date: 
17 Nov 2017
Source: 
Nature Chemical Biology
Audience: 
Professionals

Wnt (wingless)/β-catenin signaling is critical for tumor progression and is frequently activated in colorectal cancer as a result of the mutation of adenomatous polyposis coli (APC); however, therapeutic agents targeting this pathway for clinical use are lacking.

 

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