An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression

Date: 
14 Nov 2017
Source: 
Journal Cancer Cell
Audience: 
Professionals
Type of resource: 
Research

Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation to the hypoxic tumor microenvironment. Deletion analyses of the two key HIF isoforms found that HIF-1α, but not HIF-2α, was essential for the effector state in CD8+ T cells. 

 

Click here to read the Research article in full