Structural characterization of human heparanase reveals insights into substrate recognition

Date: 
19 Nov 2015
Source: 
Nature Structural & Molecular Biology
Audience: 
Professionals
Type of resource: 
Research

Heparan sulfate (HS) is a glycosaminoglycan that forms a key component of the extracellular matrix (ECM). Breakdown of HS is carried out by heparanase (HPSE), an endo-β-glucuronidase of the glycoside hydrolase 79 (GH79) family. Overexpression of HPSE results in breakdown of extracellular HS and release of stored growth factors and hence is strongly linked to cancer metastasis.