SOST Inhibits Prostate Cancer Invasion

Date: 
18 Nov 2015
Source: 
PLOS ONE
Audience: 
Professionals
Type of resource: 
Research

Inhibitors of Wnt signaling have been shown to be involved in prostate cancer (PC) metastasis; however the role of Sclerostin (Sost) has not yet been explored. Here we show that elevated Wnt signaling derived from Sost deficient osteoblasts promotes PC invasion, while rhSOST has an inhibitory effect.